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Petropolis at night
Petropolis is the main setting of T.U.F.F. Puppy. It has a prison, water park, amusement park, cinema, monorail, aquarium (which is actually an asylum), etc. Like the rest of the world, in the show, it is populated by anthropomorphic animals. Some buildings include T.U.F.F. headquarters, D.O.O.M. headquarters, etc. Some streets include the Catwalk (the street Kitty lives on), etc. The city is shown to be located in the United States; in the state of California (as shown on Bird Brain's endangered species card in Booby Trap) and is very crime-infested. It is most likely in north-western California since it receives snow.